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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Influence of Training Exercise on Clinical Plasma Chemistry Parameters and Cardiac Markers in Race Horses) ผู้เขียน: นางชูศรี ศรีเพ็ญ, ผู้ช่วยศาสตราจารย์ ,  Anuchit Sitthichaiyakul, Yuwadee Kongpiromchean, นายโฆษิต ศรีเพ็ญ, อาจารย์ สื่อสิ่งพิมพ์:pdf AbstractPhysiological variations of clinical chemistry parameters as a function of exercise reflecting general health and performance are largely unknown in race horses. To assess changes in blood biochemical variables, with special emphasis on cardiac markers, blood samples were drawn from twelve healthy race horses (6 males and 6 females; age range from 2 to 6 years) before and after the exercise training. Biochemical parameters in the renal, liver and lipid profile as well as the muscle enzymes creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were measured with standard methods using an automated analyzer Hitachi 917 (Roche Diagnostics). Cardiac troponin I (cTnI) plasma concentrations were analyzed with immunometric luminescence technology utilizing an automated immunoassay analyzer Vitros ECi (Ortho-Clinical Dianostic). With the exception of triglycerides, all other biochemical variables showed increased levels after the exercise, with values for alanine aminotransferase (ALT), albumin and total protein reaching statistical significance. The activities of CK and LDH, but not of AST, also displayed a significant increase after the training. Comparing with pre-exercise mean value of 0.015 ng/ml, a more than 10 fold increase in cTnI concentration (0.177 ng/ml) was observed, with a maximum value as high as 0.498 ng/ml. The majority of animals (58%) showed levels exceeding lower cut-off concentration of cTnI at 0.12 ng/ml indicative of a small myocyte injury. In conclusion, small changes in levels of the routine blood chemistry parameters due to training exercise are common in race horses. There was biochemical evidence of minor myocardial cell damage as assessed by cardiac troponin I plasma concentrations. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Biochemical Alterations and Their Relationships with the Metabolic Syndrome Components in Canine Obesity) ผู้เขียน:Tippayaporn Tribuddharatana, Yuwadee Kongpiromchean, นายโฆษิต ศรีเพ็ญ, อาจารย์, นางชูศรี ศรีเพ็ญ, ผู้ช่วยศาสตราจารย์ สื่อสิ่งพิมพ์:pdf AbstractMetabolic changes accompanying obesity have been intensively studied in humans but are rarely reported in animals. The present study aimed to investigate alterations of glucose metabolism and biochemical parameters in renal, lipid and liver profiles and to study their metabolic relationship determined in 31 obese dogs compared with 31 non-obese control dogs. The results showed that with the exception of creatinine and aspartate aminotransferase, all other parameters measured in obese animals exhibited significantly higher levels than those in the control group. In contrast to non-obese dogs, significant associations of glucose with several lipid parameters and liver enzymes alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were observed in obese dogs. These enzymes, on the other hand, displayed significant correlations with total cholesterol and low-density lipoprotein cholesterol, but not with high-density lipoprotein cholesterol. The results indicated that ALT and GGT may have major pathophysiological roles in obesity-related metabolic alterations and should be included as biochemical criteria of metabolic syndrome in canine obesity. |